1. SP485REN-L/TR Substitution Conclusion Direct substitution is generally not recommended. It may only be considered for non-critical applications characterized by low data rates, stable power supply, and minimal noise interference, and only after careful evaluation. The key differences are as follows: Its data rate is limited to 5 Mbps (compared to 10 Mbps for the original part), effectively halving the communication bandwidth and rendering it unsuitable for systems requiring higher transmission speeds. The supply voltage range is narrower (4.75V to 5.25V), demanding greater power supply precision and stability; reliability may degrade in environments with significant voltage fluctuations. The receiver hysteresis specification is not explicitly stated. Typically, this indicates inferior noise immunity (e.g., against signal jitter and common-mode noise) compared to the original model, which features a defined 70mV hysteresis. Collectively, these differences indicate this part is a performance-compromised alternative.