1. LTC2862MPS8-2PBF Substitution Conclusion The feasibility of substituting the LTC2862MPS8-2PBF for the ISL8485ECBZ is limited and primarily depends on the data rate requirements of the application. Key differences include the data rate (250 kbps for the LTC2862 versus 10 Mbps for the ISL8485). In systems requiring high-speed communication (e.g., 10 Mbps or higher), the LTC2862 cannot serve as a direct replacement and may create a performance bottleneck. Regarding receiver hysteresis (150 mV for the LTC2862 compared to 70 mV for the ISL8485), the LTC2862 offers stronger noise immunity, making it suitable for noisy environments, though potentially at the cost of some signal sensitivity. The supply voltage range (3V to 5.5V for the LTC2862, wider than the 4.5V to 5.5V of the ISL8485) allows the LTC2862 to be compatible with both 3.3V and 5V systems, providing greater design flexibility. Substitution may be viable if the application only requires low-speed operation (≤250 kbps) and would benefit from the wider voltage range or higher noise immunity. Otherwise, a model with a matching data rate should be selected.