1. ISL83078EIUZA-T Substitution Conclusion Direct substitution is generally not recommended and carries significant risk. While its core specifications—3.3V supply, half-duplex operation, 1/1 transceiver functionality—and data rate (20Mbps) match or even exceed the original part, its most critical deviation is the receiver hysteresis of 15 mV. This is substantially lower than the original's 100 mV. Consequently, its immunity to common-mode noise and signal jitter in noisy industrial environments will be severely degraded, significantly increasing the probability of data errors. This difference directly compromises the robustness and reliability of the communication link. Therefore, its use should only be cautiously evaluated in applications with exceptionally clean electromagnetic environments.