1. SP3078EEN-L/TR Substitution Conclusion The SP3078EEN-L/TR can functionally replace the ADM3078EYRZ-REEL7, as both support RS422/RS485 protocols, half-duplex operation, 16 Mbps data rate, and 8-SOIC packaging, ensuring electrical and mechanical compatibility. The key differences lie in the receiver hysteresis, which is reduced from 100 mV to 15 mV, significantly lowering noise immunity and potentially increasing the risk of false triggering in noisy environments; therefore, it is only suitable for applications with relatively clean signals. Additionally, the supply voltage is fixed at 3.3 V instead of the original 3 V to 3.6 V range, requiring a more precise power supply and offering less tolerance to voltage fluctuations, which may limit its suitability in battery-powered or voltage-unstable applications. Overall, substitution is feasible provided the noise environment is controlled and the supply is stable at 3.3 V; otherwise, system reliability should be re-evaluated.