1. Supply Voltage Range - BU9795ZKS2: 2.5V to 5.5V - LC75836WH-E: 4.5V to 6V The BU9795ZKS2 is compatible with both 3.3V and 5V systems, whereas the LC75836WH-E is only suitable for systems operating near 5V or higher. If the original design uses a 3.3V supply, direct replacement will result in device malfunction. 2. Quiescent Current - BU9795ZKS2: 20 µA - LC75836WH-E: 450 µA The BU9795ZKS2 exhibits significantly lower power consumption, making it suitable for battery-powered or power-sensitive applications. The LC75836WH-E consumes 22.5 times more current, which could substantially reduce system standby time or require a redesign of the power management scheme. 3. Package and Pin Count - BU9795ZKS2: 52-pin SQFP (10×10 mm) - LC75836WH-E: 48-pin SQFP (7×7 mm) The package footprint and pin count are incompatible, requiring PCB re-layout. Additionally, pin function definitions must be verified individually, introducing risk of pin mapping mismatches. 4. Manufacturer and Supply Chain - Drivers from different manufacturers may exhibit variations in internal timing, register configuration, and communication protocol details. Deep validation of software driver compatibility is essential, along with consideration of long-term supply availability and cost factors.