1. LTC2850CMS8TRPBF Substitution Conclusion The LTC2850CMS8TRPBF can serve as a direct drop-in replacement for the ISL3172EIUZ-T in terms of basic functionality and physical package. However, two critical differences must be carefully evaluated for system impact: First, the data rate difference—the LTC2850 supports 20 Mbps (high speed), whereas the ISL3172 is limited to 250 kbps (low speed). The LTC2850 is suitable for high‑frequency communication scenarios, but if the original system was designed for low‑speed operation, direct substitution may raise signal‑integrity requirements (e.g., layout must account for transmission‑line effects). Second, the receiver hysteresis differs: the LTC2850 provides 25 mV of hysteresis compared to 15 mV for the ISL3172, indicating better noise immunity, though it may slightly reduce sensitivity to weak signals. In summary, provided the system supply and logic levels are compatible and the communication rate requirement is ≤ 20 Mbps, the LTC2850 can replace the original part and offer performance margin. However, in low‑speed applications, its drive characteristics should be verified to ensure they do not introduce unnecessary EMI risks.