1. LTC2850CMS8TRPBF Substitution Conclusion The LTC2850CMS8TRPBF is a viable alternative to the ISL3178EIUZ-T. Both devices are fully compatible in their core specifications (3V to 3.6V supply, 20Mbps data rate, half-duplex RS-422/485) and package (8-MSOP), enabling a direct pin-to-pin replacement. The key difference lies in the receiver hysteresis: the LTC2850CMS8TRPBF features 25 mV of hysteresis, compared to 15 mV for the ISL3178EIUZ-T. This higher hysteresis voltage gives the LTC2850 an advantage in noise immunity, as it more effectively filters minor interference signals on the bus. Consequently, this substitution enhances communication reliability in complex electromagnetic environments. This change represents a performance improvement and does not introduce any compatibility risks to the existing design.