1. SP490EEN-L/TR Substitution Conclusion The SP490EEN-L/TR can serve as a functional drop-in replacement for the ISL8490EIBZ-T, with one key note regarding supply voltage range: the ISL8490EIBZ-T supports 4.5V to 5.5V, while the SP490EEN-L/TR requires 4.75V to 5.25V. In systems with lower supply voltages (e.g., near 4.5V), the SP490EEN-L/TR may not operate properly. However, both parts show high compatibility in typical 5V±5% designs. All other core parameters—including protocol, data rate, hysteresis, package, and driver/receiver configuration—are identical, allowing direct electrical and mechanical substitution. It is recommended to verify system supply stability before replacement, especially in applications with tight voltage margins, where targeted validation is advised.