1. ISL32495EIBZ Substitution Conclusion The ISL32495EIBZ can serve as a partial technical substitute for the ADM487EWARZ-REEL7, but careful evaluation of the application context is required. Key differences include: a reduction in receiver hysteresis from 70 mV to 25 mV, which may compromise noise immunity in electrically noisy environments and potentially impact signal stability; an increase in data rate capability from 250 kbps to 1 Mbps, supporting higher-speed communication and making it suitable for systems with greater bandwidth demands; and a widened supply voltage range from 4.75V–5.25V to 4.5V–5.5V, offering improved power supply tolerance. However, the original part's Automotive Grade qualification is not specified for the ISL32495EIBZ, which could limit its direct substitution in automotive or high-reliability industrial environments. In summary, the ISL32495EIBZ can be considered as a replacement in applications with lower environmental noise, where automotive-grade certification is not required, and where higher data rates are beneficial, provided signal integrity and long-term reliability are thoroughly validated.