1. Lower Frequency Limit: The LTC5588 supports operation down to 200 MHz, whereas the ADL5375 is specified only from 400 MHz. Consequently, the ADL5375 cannot be used in any application requiring operation between 200 MHz and 400 MHz. 2. Supply Voltage and Power Consumption: The LTC5588 operates from a 3.3V supply (drawing 303 mA), while the ADL5375 requires a 5V supply (200 mA). This not only demands a completely different power supply architecture but also necessitates modifications to the power distribution network and decoupling design, even though the total power dissipation is similar (approximately 1W for both). 3. Linearity and Output Power: The LTC5588 offers higher output P1dB (12 dBm vs. 10.4 dBm) and higher output power (4.2 dBm vs. 1.71 dBm). This indicates that the LTC5588 can deliver a stronger output signal and better linearity under identical conditions, making it more suitable for driving subsequent stages or meeting system modulation quality requirements. 4. Noise Performance: The LTC5588 exhibits a lower noise floor (-160 dBm/Hz vs. -157.6 dBm/Hz). This approximately 2.4 dB improvement directly impacts the dynamic range and signal-to-noise ratio of the modulated signal, which is critical in noise-sensitive, high-performance receive chains.