1. Non‑Volatile Memory Difference: The MCP48FEB18‑16E/ST integrates an EEPROM, which stores the output configuration and automatically restores it after power‑up. The MCP48FVB18‑16E/ST uses volatile registers, requiring reconfiguration upon each power‑cycle. The former is suitable for systems that must output a preset voltage immediately at power‑up or retain the pre‑power‑down state. The latter relies on controller initialization and is better suited for applications where configuration reload at every power‑up is acceptable. 2. Long‑Term Reliability Impact: EEPROMs have a limited number of write/erase cycles (typically around 1 million). Frequent configuration saves may affect device lifetime. The volatile version involves only register operations and does not share this concern. Consequently, the EEPROM‑based variant is not recommended for applications requiring high‑frequency, dynamic configuration storage. 3. Cost and Supply Considerations: Typically, the EEPROM‑integrated version carries a slightly higher cost and may have different lead times. In systems where state retention is unnecessary, adopting the volatile version can optimize BOM cost.