1. ADM487EWARZ Substitution Conclusion In 5V systems where the data rate requirement does not exceed 250 kbps and power supply voltage accuracy is high, the ADM487EWARZ can serve as a functional substitute for the ISL32475EIBZ, but with key performance degradations and limitations. The differences are as follows: The ADM487EWARZ supports a maximum data rate of only 250 kbps, significantly lower than the original part’s 1 Mbps, making it unsuitable for applications requiring high‑speed communication; its receiver hysteresis is 70 mV (compared to 25 mV for the original), which improves noise immunity in harsh environments but may slightly increase signal edge delay; its supply voltage range is narrower (4.75 V to 5.25 V), imposing stricter requirements on supply accuracy and introducing risk in systems with larger voltage fluctuations; additionally, it carries Automotive‑grade qualification, making it suitable for more demanding environments, though this advantage may not add value if the original design targets general industrial applications. Substitution feasibility depends heavily on the specific application’s requirements for speed, supply noise, and environmental grade.