1. ADM487EWARZ-REEL7 Substitution Conclusion Direct substitution is not recommended. While the package (8-SOIC) and basic function (half-duplex RS-485/422 transceiver) are identical, two key parametric differences preclude its direct replacement for the ISL32478EIBZ in high-performance applications. The primary discrepancy is data rate (250 kbps vs. 15 Mbps), which confines the ADM487EWARZ-REEL7 to low-speed communication scenarios. Substitution in a system originally operating at high speed will result in communication failure. Secondly, its receiver hysteresis is significantly higher (70 mV vs. 25 mV). This provides superior noise immunity in harsh environments but comes at the cost of reduced receiver sensitivity to weak differential signals, potentially compromising communication reliability on marginal transmission lines. Furthermore, its tighter supply voltage range (4.75 V to 5.25 V vs. 4.5 V to 5.5 V) offers less power supply tolerance. Its sole advantage is the "Automotive Grade" qualification, which only adds value in applications with that specific requirement.