1. SP485EMN-L Substitution Conclusion The SP485EMN-L can serve as a direct drop-in replacement for the ISL32485EIBZ in terms of package and basic functionality, but several key differences must be evaluated. Its data rate increases from 1 Mbps to 10 Mbps, offering enhanced communication capability, though this may introduce signal integrity concerns such as overshoot and ringing, necessitating a review of PCB layout and impedance matching. The supply voltage range is narrowed to 4.75 V–5.25 V (compared to the original 4.5 V–5.5 V), imposing stricter requirements on power supply stability; insufficient voltage margin in the original design could lead to operational anomalies. Additionally, the receiver hysteresis is reduced from 25 mV to 20 mV, slightly degrading noise immunity, which requires careful validation in high-noise environments. In summary, substitution is feasible if the system power supply meets the tighter tolerance and the application environment is noise-controlled, but bench validation is strongly recommended.