1. SP1485EEN-L/TR Substitution Conclusion This part is a viable substitute, though potential impacts due to performance differences must be considered. The key variances are: its data rate is significantly higher (20Mbps vs. 1Mbps), offering superior performance in high-speed communication applications. However, on a bus originally optimized for 1Mbps, the excessive rate may exacerbate signal integrity issues, necessitating a re-evaluation of the board layout. The receiver hysteresis is slightly lower (20mV vs. 25mV), resulting in marginally reduced noise immunity in electrically noisy environments. The supply voltage range is narrower (4.75V to 5.25V vs. 4.5V to 5.5V), imposing a slightly stricter requirement on power supply stability; confirmation is needed for marginal scenarios with significant voltage fluctuations. Overall, in a typical 5V system, it can serve as a drop-in replacement and offers headroom for higher communication speeds. However, if the original design has limited margin, signal quality may require closer attention.