1. INA141UA/2K5G4 Substitution Conclusion Feasible, but constitutes a conditional substitution requiring careful evaluation of its impact on the input signal source. The key differences are its input bias current (2nA), which is 25 times higher than the original part (80pA), and its slew rate (4V/µs), which is over 3 times faster than the original (1.2V/µs). In applications with high source impedance (e.g., photodiodes, pH electrodes), the higher bias current will generate a larger input offset voltage error and increase input current noise, potentially degrading system DC accuracy significantly. While the faster slew rate is beneficial for handling rapid transient signals, it offers limited overall speed improvement in a circuit with the same 1MHz bandwidth. Substitution is viable if your application uses a low-impedance front-end source (e.g., bridge circuits, low-resistance sensors) and values its slightly lower quiescent current (750µA vs. 900µA).