1. Channel Function Definition: The LP5814DRLR is an RGBW driver, with its four channels preset to drive red, green, blue, and white LEDs. The LP5816DRLR is an RG driver; its channels are likely optimized or allocated only for red and green LEDs. In terms of software configuration, differences may exist in channel mapping, independent dimming control logic, or internal register settings. For applications requiring independent and precise control of the white channel, direct substitution may result in the white color channel failing to achieve the intended performance. 2. Functionality and Cost Optimization Orientation: Given identical core electrical parameters, package, and interface, the lower price of the LP5816 suggests it may be a functionally simplified or optimized version introduced by TI for specific markets (e.g., dual-color indicators, basic RGB applications). When considering substitution, it is essential to confirm whether the LP5816 fully supports all control functions required for RGBW (such as independent PWM registers for the W channel and compatibility with color mixing algorithms), rather than merely having the same number of physical channels. Recommendation: Provided that hardware pin compatibility is confirmed, a detailed comparison of the register maps, channel configuration bits, and application circuit examples in both datasheets must be conducted prior to substitution to verify software driver compatibility. If the original design fully utilizes the independent white channel, the risk of substitution is high. If only RGB functionality is used, substitution is more feasible.