1. AS358AMTR-G1 Substitution Conclusion The AS358AMTR-G1 meets the substitution criteria in terms of package compatibility (8-SOIC) and supply voltage range (partially overlapping). However, significant differences in key performance parameters make direct substitution for the TLE2061CD inadvisable. The primary discrepancies include: input bias current (20 nA vs. 4 pA), which is 5000 times higher in the AS358, rendering it unsuitable for weak signal acquisition applications such as high-impedance sensors; input offset voltage (2 mV vs. 600 µV), approximately 3.3 times worse, leading to substantial degradation in DC accuracy; bandwidth and slew rate (not specified for AS358) are likely far lower than those of the TLE2061 (2 MHz GBW, 3.4 V/µs), limiting dynamic signal processing capability. Additionally, the AS358 is a dual-channel amplifier, whereas the TLE2061 is single-channel, requiring attention to circuit layout and power distribution (the AS358 exhibits higher quiescent current). Substitution may be cautiously considered only in multi-channel general-purpose amplification scenarios with extremely low requirements for precision, speed, and noise. Otherwise, system performance degradation is likely.