1. Isolation Voltage: The AVO50 offers an isolation voltage of 2kV, higher than the QW010's 1.5kV. This provides the AVO50 with greater robustness against high-voltage transients (e.g., lightning strikes, inductive load switching) between its input and output, making it more suitable for industrial or communications environments with stringent safety isolation or EMC requirements. 2. Physical Size & Package: The AVO50 has a width of 22.9mm (standard 1/8 Brick), significantly narrower than the QW010's 36.8mm. This not only saves PCB area but, more importantly, its industry-standard "brick" package typically implies a more optimized internal layout, more mature manufacturing processes, and potentially better thermal distribution. Verification of compatibility with the existing thermal management design and mechanical mounting is necessary. 3. Control Characteristics: The QW010 explicitly specifies "Enable, Active Low" control, while the AVO50 datasheet lacks detailed description. The two modules may differ in their Remote On/Off enable logic (active-high vs. active-low). A direct substitution could lead to system power-up sequencing failure. The AVO50's detailed specifications must be consulted to confirm its logic. 4. Efficiency: The QW010 has a nominal efficiency of 92%, slightly higher than the AVO50's 91%. At full 50W load, the AVO50's power dissipation is approximately 0.5W higher, which may lead to a marginally higher module temperature rise. The impact on the overall system thermal design should be evaluated for high-temperature or confined space applications.