1. Substitution Conclusion for ADM3485EARZ-REEL7 The ADM3485EARZ-REEL7 cannot be used as a direct drop-in replacement for the LTC1482IS8TRPBF, primarily due to two key technical differences: supply voltage (the ADM3485 is designed for 3.3V systems, while the LTC1482 operates at 5V) and data rate (the ADM3485 supports up to 10Mbps, compared to 4Mbps for the LTC1482). If the original design uses a 5V supply, substituting the part would require modifying the power architecture; otherwise, the device may fail to operate or be damaged. Although the higher data rate of the ADM3485 indicates superior performance, it must be matched with appropriate line impedance and termination design to avoid signal integrity issues at high speeds. Additionally, the ADM3485 features better receiver hysteresis (50mV) than the LTC1482 (30mV), providing improved noise immunity. However, this advantage is only realized if the voltage compatibility is first ensured. In summary, substitution requires a thorough re-evaluation of the power supply scheme and signal chain design; direct plug-and-play replacement is not feasible.